Association of early protein intake and pre-peritoneal fat at five years of age: Follow-up of a randomized clinical trial

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Gruszfeld, D. ; Weber, M. ; Gradowska, K. ; Socha, P. ; Grote, V. ; Xhonneux, A. ; Dain, E. ; Verduci, E. ; Riva, E. ; Closa-Monasterolo, R. ; Escribano, J. ; Koletzko, B.

Childrens Mem Hlth Inst

关键词: Infant formula;    Protein;    Dietary proteins;    Intra-abdominal fat;    Subcutaneous fat;    Child;   

DOI  :  10.1016/j.numecd.2016.04.005

学科分类：食品科学和技术

【 摘 要 】

Background and aims: The double-blind randomized European Childhood Obesity Project (CHOP) demonstrated that reduced protein content in infant formula leads to a lower body mass index (BMI) up to six years of age. Here we aimed at assessing pre-peritoneal fat, a marker of visceral fat, in children participating in the CHOP trial. Methods and results: Healthy term formula-fed infants in five European countries were randomized either to higher (n = 550) or lower (n = 540) protein formulas in the first year of life. Infants who were exclusively breastfed for at least three months (n = 588) were enrolled as an observational (non randomized) group. At age 5 years, subcutaneous fat (SC) and pre-peritoneal fat (PP) were measured by ultrasound in a subgroup of 275 children. The PP fat layer was thicker in the higher compared to the lower protein group (adjusted estimated difference: 0.058 cm, 95% CI 0.002; 0.115; p = 0.043), while SC fat was not different. Girls showed a thicker SC fat layer than boys. Conclusions: Higher protein intake in formula-fed infants appears to enhance pre-peritoneal fat tissue accumulation at the age of 5 years, but not of subcutaneous fat, which may trigger adverse metabolic and health consequences. (C) 2016 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.