Infants fed formula with added long chain polyunsaturated fatty acids have reduced incidence of respiratory illnesses and diarrhea during the first year of life

BMC Pediatrics

Deolinda MF Scalabrin¹  Weihong Zhuang¹  Nitida Pastor¹  Alexandre Lapillonne² 

[1] Department of Medical Affairs, Clinical Research, Mead Johnson Nutrition, Evansville, USA;Department of Neonatology, APHP Necker Enfants Malades Hospital, Paris Descartes University, Paris, France

关键词: Diarrhea;    Respiratory illness;    Infant nutrition;    Infant formula;    Infant;    LCPUFAs;    ARA;    DHA;   

Others  :  1138617
DOI  :  10.1186/1471-2431-14-168

 received in 2014-02-27, accepted in 2014-06-25,  发布年份 2014

【 摘 要 】

Background

Long chain polyunsaturated fatty acids (LCPUFAs) may influence the immune system. Our objective was to compare the frequency of common illnesses in infants who received formula with or without added LCPUFAs.

Methods

In this observational, multi-center, prospective study, infants consumed formula with 17 mg DHA and 34 mg ARA/100 kcal (n = 233) or with no added DHA or ARA (n = 92). Pediatricians recorded respiratory illnesses, otitis media, eczema, and diarrhea through 1 year of age.

Results

Infants who consumed formula with DHA/ARA had lower incidence of bronchitis/bronchiolitis (P = 0.004), croup (P = 0.044), nasal congestion (P = 0.001), cough (P = 0.014), and diarrhea requiring medical attention (P = 0.034). The odds ratio (OR) of having at least one episode of bronchitis/bronchiolitis (0.41, 95% CI 0.24, 0.70; P = 0.001), croup (0.23, 95% CI 0.05, 0.97; P = 0.045), nasal congestion (0.37, 95% CI 0.20, 0.66; P = 0.001), cough (0.52, 95% CI 0.32, 0.86; P = 0.011), and diarrhea requiring medical attention (0.51, 95% CI 0.28, 0.92; P = 0.026) was lower in infants fed DHA/ARA. The OR of an increased number of episodes of bronchitis/bronchiolitis, croup, nasal congestion, cough, and diarrhea, as well as the hazard ratio for shorter time to first episode of bronchitis/bronchiolitis, nasal congestion, cough, and diarrhea were also significantly lower in the DHA/ARA group.

Conclusions

In healthy infants, formula with DHA/ARA was associated with lower incidence of common respiratory symptoms and illnesses, as well as diarrhea.

【 授权许可】

   
2014 Lapillonne et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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