Metformin enhanced in vitro radiosensitivity associates with G2/M cell cycle arrest and elevated adenosine-5’-monophosphate-activated protein kinase levels in glioblastoma

Radiology and Oncology

Sebastian Adeberg¹  Michael Repka²  Juergen Debus³  Nils H. Nicolay³  Klaus-Josef Weber⁴  Angela Mohr⁵  Stefan Rieken⁵  Denise Bernhardt⁵  Juliane Hörner-Rieber⁵  Semi B. Harrabi⁵  Laila König⁵  Amir Abdollahi⁶ 

[1] Corresponding authorUniversity Hospital of Heidelberg, Department of Radiation Oncology, Heidelberg, GermanyClinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, GermanyHeidelberg Ion-Beam Therapy Center (HIT), Heidelberg, GermanyHeidelberg Institute for Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany;Department of Radiation Medicine, Georgetown University Hospital, Washington DC, USAOther articles by this author:;University Hospital of Heidelberg, Department of Radiation Oncology, Heidelberg, GermanyClinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, GermanyHeidelberg Ion-Beam Therapy Center (HIT), Heidelberg, GermanyHeidelberg Institute for Radiation Oncology, University Hospital of Heidelberg, Heidelberg, GermanyOther articles by this author:;University Hospital of Heidelberg, Department of Radiation Oncology, Heidelberg, GermanyHeidelberg Institute for Radiation Oncology, University Hospital of Heidelberg, Heidelberg, GermanyOther articles by this author:;University Hospital of Heidelberg, Department of Radiation Oncology, Heidelberg, GermanyHeidelberg Ion-Beam Therapy Center (HIT), Heidelberg, GermanyHeidelberg Institute for Radiation Oncology, University Hospital of Heidelberg, Heidelberg, GermanyOther articles by this author:;University Hospital of Heidelberg, Department of Radiation Oncology, Heidelberg, GermanyHeidelberg Ion-Beam Therapy Center (HIT), Heidelberg, GermanyHeidelberg Institute for Radiation Oncology, University Hospital of Heidelberg, Heidelberg, GermanyTanslational Radiation Oncology, German Cancer Consortium (DKTK), National Center for Tumor Diseases German Cancer Research Center (DKFZ), Heidelberg, GermanyOther articles by this author:

关键词: metformin;    glycolysis;    metabolism;    gliomas;    proliferation;    cell cycle;   

DOI  :  10.1515/raon-2017-0042

学科分类：肿瘤学

来源: Onkoloski Institut Ljubljana / Institute of Oncology Ljubljana

【 摘 要 】

BackgroundIt is hypothesized that metabolism plays a strong role in cancer cell regulation. We have recently demonstrated improved progression-free survival in patients with glioblastoma who received metformin as an antidiabetic substance during chemoradiation. Although metformin is well-established in clinical use the influence of metformin in glioblastoma is far from being understood especially in combination with other treatment modalities such as radiation and temozolomide.

【 授权许可】

Unknown