When needles look like hay: How to find tissue-specific enhancers in model organism genomes

Developmental biology

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关键词: Cis-regulatory element;    Fish;    Zebrafish;    Medaka;    Transgenesis;    Cis-regulation;    Transcriptional regulation;    Non-coding elements;    Genome analysis;    Enhancers;   

DOI  :  10.1016/j.ydbio.2010.11.026

学科分类：生物科学（综合）

来源: Academic Press

【 摘 要 】

A major prerequisite for the investigation of tissue-specific processes is the identification of cis-regulatory elements. No generally applicable technique is available to distinguish them from any other type of genomic non-coding sequence. Therefore, researchers often have to identify these elements by elaborate in vivo screens, testing individual regions until the right one is found.

【 授权许可】

CC BY