Case report of myeloperoxidase deficiency associated with disseminated paracoccidioidomycosis and peritoneal tuberculosis

Sociedade Brasileira de Medicina Tropical. Revista

Levy, Ariel¹  Bertolini, Dalton Luis¹  Domingues-Ferreira, Maurício¹  Vasconcelos, Dewton de Moraes¹  Barros, Noac Chuffi¹ 

[1] Universidade de São Paulo, São Paulo, Brazil

关键词: Myeloperoxidase deficiency;    Paracoccidioides brasiliensis;    Mycobacterium tuberculosis.;   

DOI  :  10.1590/0037-8682-0462-2016

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

Myeloperoxidase (MOP) is present in monocyte and neutrophil lysosomes, catalyzing hydrogen peroxide and chloride ion conversion to hypochlorous acid. MOP seems to destroy pathogens during phagocytosis by neutrophils and is considered an important defense against innumerous bacteria. We present a patient who had MOP deficiency, who presented with a subacute form of paracoccidioidomycosis and later with peritoneal tuberculosis. MOP deficiency leads to the diminished destruction of phagocytized pathogens. This case gives important evidence of an association between MOP deficiency and increased susceptibility to infection by Paracoccidioides brasiliensis and Mycobacterium tuberculosis.

【 授权许可】

CC BY