Sociedade Brasileira de Medicina Tropical. Revista | |
Case report of myeloperoxidase deficiency associated with disseminated paracoccidioidomycosis and peritoneal tuberculosis | |
Levy, Ariel1  Bertolini, Dalton Luis1  Domingues-Ferreira, MaurÃcio1  Vasconcelos, Dewton de Moraes1  Barros, Noac Chuffi1  | |
[1] Universidade de São Paulo, São Paulo, Brazil | |
关键词: Myeloperoxidase deficiency; Paracoccidioides brasiliensis; Mycobacterium tuberculosis.; | |
DOI : 10.1590/0037-8682-0462-2016 | |
学科分类:农业科学(综合) | |
来源: Sociedade Brasileira de Medicina Tropical | |
【 摘 要 】
Myeloperoxidase (MOP) is present in monocyte and neutrophil lysosomes, catalyzing hydrogen peroxide and chloride ion conversion to hypochlorous acid. MOP seems to destroy pathogens during phagocytosis by neutrophils and is considered an important defense against innumerous bacteria. We present a patient who had MOP deficiency, who presented with a subacute form of paracoccidioidomycosis and later with peritoneal tuberculosis. MOP deficiency leads to the diminished destruction of phagocytized pathogens. This case gives important evidence of an association between MOP deficiency and increased susceptibility to infection by Paracoccidioides brasiliensis and Mycobacterium tuberculosis.
【 授权许可】
CC BY
【 预 览 】
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