Systemic paracoccidioidomycosis in a patient with enzymatic myeloperoxidase deficiency and acute lymphoblastic leukemia: case report

Bulletin of the National Research Centre

Case Report

Cristián Camilo Agudelo¹  Diana Mercedes Lozano²  Sebastián Hoyos³  Luis Eduardo Buitrago⁴ 

[1] Internal Medicine Resident, Universidad de Antioquia, Medellín, Antioquia, Colombia;Pathology Laboratory, Clínica Somer, Rionegro, Antioquia, Colombia;Stem Cell Transplant Unit, Clínica Somer, Rionegro, Antioquia, Colombia;Stem Cell Transplant Unit, Hospital Pablo Tobón Uribe, Medellín, Antioquia, Colombia;

关键词: Case report;    Myeloperoxidase deficiency;    Paracoccidioidomycosis;    Acute lymphoblastic leukemia lymphoblastic;    Enzymatic deficiency;   

DOI  :  10.1186/s42269-022-00973-z

 received in 2022-11-23, accepted in 2022-12-17,  发布年份 2022

来源: Springer

【 摘 要 】

BackgroundParacoccidioidomycosis is a systemic fungal infection that is potentially fatal, and the most prevalent of its kind in Latin America. The predisposition to infection appears to be related to abnormalities in cellular immunity, given its low prevalence in endemic regions. The role of myeloperoxidase deficiency has not been elucidated.Case presentationWe present a case of 48-year-old female patient with acute lymphoblastic leukemia, stem cell transplant candidate, who developed a fever with lymphadenopathy and lung nodules, consistent with paracoccidioidomycosis infection, in whom a myeloperoxidase deficiency was later discovered. The treatment of the hematologic malignancy had a good impact solving the enzymatic deficiency and antifungal therapy achieve controlling the infection.ConclusionsThis case lays out the possible association between acute leukemia, an alteration in neutrophil function (needed to fight fungal infections) and an infection due to Paracoccidioides brasiliensis.

【 授权许可】

CC BY   
© The Author(s) 2022

【 图 表 】

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Fig. 2