The long-term safety of D-allulose administration in healthy dogs

The Journal of Veterinary Medical Science

Masaaki TOKUDA¹  Naohito NISHII²  Satoshi TAKASHIMA²  Hitoshi KITAGAWA²  Yui KOBATAKE² 

[1] Department of Cell Physiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793, Japan;Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan

关键词: D-allulose;    dog;    safety;   

DOI  :  10.1292/jvms.17-0367

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

The safety and biological effects of a long-term dose of D-allulose were evaluated in healthy dogs. For 12 weeks, the dogs were administered D-allulose (0.2 g/kg) or placebo daily. Plasma total cholesterol concentrations in the D-allulose group were significantly lower than those in the control group at and after week 2 (P<0.05). D-Allulose administration did not cause clinical signs or changes in hematological and biochemical levels, except for lipids. D-Allulose administration also did not influence body weight. Plasma glucose and insulin concentrations in the glucose tolerance test, performed one day after the termination of D-allulose administration, were not different between groups, suggesting no cumulative effects of D-allulose on glucose metabolism in healthy dogs. In conclusion, long-term administration of D-allulose caused no harmful effects in dogs.

【 授权许可】

Unknown