The Journal of Veterinary Medical Science | |
The long-term safety of D-allulose administration in healthy dogs | |
Masaaki TOKUDA1  Naohito NISHII2  Satoshi TAKASHIMA2  Hitoshi KITAGAWA2  Yui KOBATAKE2  | |
[1] Department of Cell Physiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793, Japan;Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan | |
关键词: D-allulose; dog; safety; | |
DOI : 10.1292/jvms.17-0367 | |
学科分类:兽医学 | |
来源: Japanese Society of Veterinary Science | |
【 摘 要 】
The safety and biological effects of a long-term dose of D-allulose were evaluated in healthy dogs. For 12 weeks, the dogs were administered D-allulose (0.2 g/kg) or placebo daily. Plasma total cholesterol concentrations in the D-allulose group were significantly lower than those in the control group at and after week 2 (P<0.05). D-Allulose administration did not cause clinical signs or changes in hematological and biochemical levels, except for lipids. D-Allulose administration also did not influence body weight. Plasma glucose and insulin concentrations in the glucose tolerance test, performed one day after the termination of D-allulose administration, were not different between groups, suggesting no cumulative effects of D-allulose on glucose metabolism in healthy dogs. In conclusion, long-term administration of D-allulose caused no harmful effects in dogs.
【 授权许可】
Unknown
【 预 览 】
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RO201902196428662ZK.pdf | 783KB | download |