Electrophysiological and histopathological findings of muscular disease suspected as myotonic dystrophy in a Shiba dog

The Journal of Veterinary Medical Science

Seiichi OKUNO¹  James K. CHAMBERS²  Kazuyuki UCHIDA²  Takanori SHIGA²  Hiroyuki NAKAYAMA² 

[1] Animal Clinic Kobayashi, 715-1, Sakai, Fukaya-shi, Saitama 366-0813, Japan;Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan

关键词: dog;    immunohistochemistry;    mitochondria;    muscle;    myotonic dystrophy;   

DOI  :  10.1292/jvms.17-0459

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

An 8-year-old male Japanese Shiba exhibited muscle wasting and a stiff gait. A low-amplitude myotonic discharge was recorded by needle electromyography (EMG). A histopathological examination on a tru-cut biopsy sample from the muscle revealed myofiber size variations. Internal nuclei and cytoplasmic vacuoles were observed in many fibers. A type 1 fiber predominance and many hybrid type fibers were observed immunohistochemically. On the basis of these EMG and histopathological findings, myotonic dystrophy (DM) was suspected as tentative diagnosis. The cytoplasm around the vacuoles was immunopositive for cytochrome c, tom 20, and SOD-1, suggesting that these vacuoles might occur within mitochondria. Collectively, these results indicate that a mitochondrial abnormality partly play the role on the pathogenesis of present case.

【 授权许可】

Unknown