Colorectal cancer liver metastases organoids retain characteristics of original tumor and acquire chemotherapy resistance - ScienceDirect

Stem Cell Research

Jon N. Buzzelli¹ 

关键词: Organoid;    Liver metastasis;    Colorectal cancer;    Chemotherapy resistance;   

DOI  :  10.1016/j.scr.2018.01.016

学科分类：生物科学（综合）

来源: Elsevier

【 摘 要 】

BackgroundColorectal cancer (CRC) liver metastasis is highly unfavorable for patient outcome and is a leading cause of cancer-related death. Pre-clinical research of CRC liver metastasis predominately utilizes CRC cell lines grown in tissue culture. Here, we demonstrate that CRC liver metastases organoids derived from human specimens recapitulate some aspects of human disease.

【 授权许可】

Unknown