Acta Chromatographicae | |
Determination of vortioxetine in human serum and saliva samples by HPLC–DAD and HPLC–MS | |
M. Waksmundzka-Hajnos1  A. Petruczynik1  K. Wróblewski1  B. Buszewski2  M. Szultka-Młyńska3  H. Karakuła-Juchnowicz4  | |
[1] 1Department of Inorganic Chemistry Medical University of Lublin, Chodźki 4a 20-093 Lublin, Poland;2Department of Environmental Chemistry and Bioanalytics, Nicolaus Copernicus University, Faculty of Chemistry Gagarina 7, PL-87-100 Toruń, Poland;3Centre for Modern Interdisciplinary Technologies, Nicolaus Copernicus University, Wileńska 4, Toruń, Poland;4Department of Clinical Neuropsychiatry, Medical University of Lublin, Głuska 2, 20-439 Lublin, Poland | |
关键词: vortioxetine; HPLC-DAD; HPLC-MS; human serum; human saliva; | |
DOI : 10.1556/1326.2017.29.3.02 | |
学科分类:化学(综合) | |
来源: Akademiai Kiado Rt. | |
【 摘 要 】
Vortioxetine is a new drug against major depressive disorder with high affinity for a range of different serotonergic targets in the central nervous system. Therapeutic drug monitoring is an important tool for the clinical management of patients receiving a pharmacotherapy, particularly in psychiatry. For this reason, determination of drug concentration in biological fluids is important for a rational dosage of drugs. Rapid and reliable analytical assays are also required to detect and identify drugs of toxicological importance. For analysis of vortioxetine by high-performance liquid chromatography (HPLC), no procedures for its determination in saliva have been reported and there are only a few ones for its determination in serum. A sensitive and selective highperformance liquid chromatography with diode array detector (HPLC-DAD) or mass spectrometer (HPLC-MS) method was developed for the fast quantification of vortioxetine in human saliva and serum. The determination was performed on a Synergi Polar RP column in isocratic mode under the optimal mobile phase containing 70% methanol, 20% acetate buffer at pH 3.5, 10% double distilled water, and 0.025 M L−1 diethylamine.
【 授权许可】
Unknown
【 预 览 】
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