Review of a New Multimodal Antidepressant Vortioxetine

Acta Medica Martiniana

Ondrejka I¹  Oppa M²  Cesnekova D²  Nosalova G² 

[1] Clinic of Psychiatry, Slovakia;Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin and University Hospital Martin, 1Department of Pharmacology;

关键词: vortioxetine;    depression;    inadequate response;    cognitive function;    sexual dysfunction;   

DOI  :  10.1515/acm-2016-0011

来源: DOAJ

【 摘 要 】

Vortioxetine is a novel antidepressant with two mechanisms of action – direct effect on several serotonin receptors and serotonin re-uptake inhibition. It shows antidepressant, anxiolytic and cognitive effects during the treatment of major depressive disorder (MDD). The aim of this article was to summarize the use of vortioxetine in clinical studies and assess the efficacy and tolerability. Most of the studies reported a statistically significant efficacy for vortioxetine versus placebo. In addition, vortioxetine showed efficacy in patients with an inadequate response to selective serotonin re-uptake inhibitors (SSRI) or serotonin-noradrenaline re-uptake inhibitors (SNRI) monotherapy and improved cognitive function in patients with MDD. In these studies, vortioxetine was well tolerated – most common observed adverse effect was nausea – and it was not associated with clinically important changes in laboratory test results or vital signs. Vortioxetine showed a relatively low incidence of sexual dysfunction.

【 授权许可】

Unknown