COMPPRATIVE STUDY OF OXIDATIVE STRESS IN PREGNANCY INDUCED HYPERTENSION PREECLAMPSIA AND ECLAMPSIA

International Journal of Biomedical and Advance Research

Sheena P S

关键词: s Pregnancy Induced Hypertension Pre-eclampsia;    Eclampsia;    Malondialdehyde;    Superoxide dismutase;    Catalase;   

学科分类：药学、药理学、毒理学（综合）

来源: Scholar Science Journals

【 摘 要 】

Background and Objective: A Hypertensive disorder of pregnancy is an important cause of maternal mortality and preeclampsia. The present study is centered on the concept that a derangement if any, in the oxidant antioxidant equilibrium during Pregnancy Induced Hypertension, Preeclampsia and Eclampsia.  Materials and Methods: Defined groups of Pregnancy Induced Hypertension, Pre-eclampsia and eclampsia patients were selected with written informed consent with fifty subjects in each group. Blood sample was collected by venous puncture and centrifuged to get serum. The estimation of Malondialdehyde, Superoxide dismutase and catalase   in three different groups was done using standard spectrophotometric method. The data were expressed as Mean ± SD. Comparison of oxidative stress between patients and controls was performed using unpaired’ rest. P value less than 0.05 was considered significant.  Results: The level of MDA was e significantly increased in (P<0.001) in PIH group but, the level of SOD and Catalase was significantly less (P<0.01). The level of MDA and Catalase in preeclampsia was significantly increased (P<0.001) but, the activity of SOD was decreased significantly (P<0.001). Similarly, in preeclampsia and Eclampsia group. When the serum MDA and catalase activity in erythrocytes and SOD level in PIH, Preeclampsia and Eclampsia were compared with normal group has shown a significant increase (P<0.001) in MDA and Catalase but significant decline (P<0.001) in SOD level respectively in all the groups.  Conclusion: In PIH, Preeclampsia and Eclampsia there is an imbalance between lipid peroxides and the antioxidant system.

【 授权许可】

CC BY