The Effects of Ginseng Java Roots (Talinum Paniculatum) extract on Malondialdehyde (MDA) levels in Male White Sprague Dawley Rats with Forced Swimming Test Model

9th Annual Basic Science International Conference 2019

自然科学（总论）

Mudigdo, Ambar^1^2 ; Riyana, Adies^2 ; Wasita, Brian^1^2

Nutrition Science, Postgraduate Program, Universitas Sebelas Maret, Ir. Sutami Street No. 36 A, Kentingan, Jebres, Central Java, Surakarta

57126, Indonesia^1

Department of Anatomical Pathology, Faculty of Medicine, Universitas Sebelas Maret, Ir. Sutami Street 36 A, Kentingan, Jebres, Surakarta

57126, Indonesia^2

关键词: Chemical species;    Chronic disease;    ginseng java roots extract;    Malondialdehyde;    Negative control;    Positive control group;    Sprague-Dawley rats;    Treatment group;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/546/6/062025/pdf
DOI  :  10.1088/1757-899X/546/6/062025

学科分类：自然科学（综合）

来源: IOP

【 摘 要 】

Intoduction: Cell and tissue damage can be caused by chemical species which known as free radical. Free radical is a highly reactive molecule and in excessive amount it can cause an oxidative stress which causes numerous chronic diseases. The ginseng java plant (Talinum Paniculatum (Jacq) Gaertn) contains various types antioxidants which can neutralize free radicals, such as flavonoid, saponin, alkaloid, tannin, quinone, and provitamin A. Aims: This study aims to analyze the effects of ginseng java roots (Talinum Paniculatum) extract on Malondialdehyde (MDA) levels in male white Sprague Dawley rats with a forced swimming test model. Methods: This study used 30 Sprague Dawley rats which were assigned into 5 different groups, such as the negative control group, positive control group, ginseng roots extract dose of 0.35 mg/200g rats body weight/day group, ginseng roots extract dose of 0.70mg/200g rats body weight/day group, and ginseng roots extract dose of 1.40 mg/200g rats body weight/day group. On the 28th and 35th day the Sprague Dawley rats were treated with a Forced Swimming Test model. The MDA level was measured on the 28th and 35th day using TBARS assay method and statistical analyze by Kruskall Wallis test with p value less than 0.05 was considered significant. Results: This study showed that the administration of ginseng java roots extract dose of 0.35 mg/200g rats body weight/day, dose of 0.70mg/200g rats body weight/day, and dose of 1.40 mg/200g rats body weight/day were significantly lowering the MDA level (p