Lab-on-a-chip fluorescence detection with image sensor and software-based image conditioning

Bulletin of the Polish Academy of Sciences. Technical Sciences

R. WalczakFaculty of Microsystem Electronics and Photonics, Wroc?aw University of Technology, 11/17 Janiszewski St., 50-372 Wroc?aw, PolandInstitute of Electron Technology, 32/46 Lotników Ave., 02-668 Warszawa, PolandOther articles by this author:De Gruyter OnlineGoogle Scholar¹ 

[1] Faculty of Microsystem Electronics and Photonics, Wroc?aw University of Technology, 11/17 Janiszewski St., 50-372 Wroc?aw, Poland

关键词: Keywords: fluorescence;    microfluidics;    lab-on-a-chip;    point-of-care;   

DOI  :  10.2478/v10175-011-0020-3

学科分类：工程和技术（综合）

来源: Polska Akademia Nauk * Centrum Upowszechniania Nauki / Polish Academy of Sciences, Center for the Advancement of Science

【 摘 要 】

The fluorometric detection in lab-on-a-chip devices for life-sciences is one of the main detection methods. Well know from "large-scale" analytical chemistry methodologies and instrumentation has been applied in lab-on-a-chip solutions. In most cases, optical instrumentation for fluorescence induction and detection is based on configuration and components borrowed from large laboratory instruments. As a result, optical instrumentation surrounding lab-on-a-chip is bulky, expensive and dedicated for operation only inside laboratory. In this paper a discussion on fluorescence detection in lab-on-a-chip is carried out. A novel image sensor - based detection instrumentation co-working with a "clever" software is described. Instrumentation is dedicated for operation in portable and low-cost devices for different life-science applications. Examples of applications of the novel method and instrumentation co-working with various lab-on-a-chips are presented on the base of author's works.

【 授权许可】

Unknown