CMOS Time-Resolved, Contact, and Multispectral Fluorescence Imaging for DNA Molecular Diagnostics

Sensors

Nan Guo¹  Ka Wai Cheung¹  Hiu Tung Wong¹ 

[1] Department of Physics and Materials Science, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong;

关键词: CMOS;    FRET;    lab-on-a-chip;    microsystem;    fluorescence spectroscopy;    multispectral imaging;    contact imaging;    quantum dots;    DNA analysis;    point-of-care;    medical diagnostics;    time-resolved;    TCSPC;   

DOI  :  10.3390/s141120602

来源: mdpi

【 摘 要 】

Instrumental limitations such as bulkiness and high cost prevent the fluorescence technique from becoming ubiquitous for point-of-care deoxyribonucleic acid (DNA) detection and other in-field molecular diagnostics applications. The complimentary metal-oxide-semiconductor (CMOS) technology, as benefited from process scaling, provides several advanced capabilities such as high integration density, high-resolution signal processing, and low power consumption, enabling sensitive, integrated, and low-cost fluorescence analytical platforms. In this paper, CMOS time-resolved, contact, and multispectral imaging are reviewed. Recently reported CMOS fluorescence analysis microsystem prototypes are surveyed to highlight the present state of the art.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.