Hepatic antioxidative potential of ethyl acetate fraction of Cynodon dactylon in Balb/c mice

Dynamic Chiropractic

关键词: Cynodon dactylon;    antioxidants;    Balb/c mice;    ethyl acetate fraction.;   

DOI  :  

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

A study was undertaken to evaluate the antioxidative potential of ethyl acetate fraction ofCynodon dactylonin Balb/c mice. In this present study mice were divided into the two groups and each group containing 6 mice. Group I mice were orally administered with 70 µl of DMSO and are the vehicle control for ethyl acetate fraction. Group II mice were injected with ED50 70 µl of ethyl acetate fraction ofC. dactylon.The activity of enzymic antioxidants (U/ mg of protein) such as catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPX) were found to be significantly high in ethyl acetate fraction treated mice when compared to the control mice. The levels (g liver tissue) of nonenzymic antioxidants such as vitamin A, vitamin C, vitamin E and reduced glutathione in the ethyl acetate fraction treated mice (Vitamin A 158.224 μg, Vitamin C 7.442 μg, Vitamin E 5.383 μg and reduced GSH 489.283 nmoles) was found to be significantly higher than that found in control mice. These results suggest thatethyl acetate fraction ofC. dactylonhas very good antioxidant and hepatic protective effect of normal oxidative stress in Balb/c mice. Currently, the importance of oxidative stress in the patho physiology of many human disorders has been highlighted, thus use of this plant as an herbal medicine is highly recommended. Hereafter, trials to establish efficacy and optimum dosage of the present herbal product for treating human chronic diseases with pathophysiology of oxidative stress are essential.

【 授权许可】

Unknown