Detection of cortical lesions in multiple sclerosis: A new imaging approach:

Multiple Sclerosis Journal – Experimental, Translational and Clinical

Kevin R Patel¹  Enrique Alvarez²  Laura Piccio³  Anne H Cross³  Robert E Schmidt⁴  Dmitriy A Yablonskiy⁵  Jie Luo⁶ 

[1] Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, USA;Department of Neurology, University of Colorado School of Medicine, USA;Department of Neurology, Washington University School of Medicine in St. Louis, USA;Department of Pathology, Division of Neuropathology, Washington University School of Medicine in St. Louis, USA;Department of Radiology, Washington University School of Medicine in St. Louis, USA;Research Laboratory of Electronics, Massachusetts Institute of Technology, USA

关键词: Multiple sclerosis;    imaging;    diagnostic;    magnetic resonance imaging;    brain imaging;    gray matter;    cerebral cortex;   

DOI  :  10.1177/2055217315606465

学科分类：医学（综合）

来源: Sage Journals

【 摘 要 】

Cortical lesions occur early in multiple sclerosis (MS) and are thought to have clinical implications. Conventional MRI is insensitive to cortical pathology. Investigational imaging modalities show improved but incomplete cortical lesion detection and are time and resource intensive. Gradient echo plural contrast imaging (GEPCI) is sensitive to MS white matter pathology and can be performed on standard MRI scanners. Here we used GEPCI to examine autopsied MS frontal brain tissues. Two cortical MS lesions were visually distinguished from surrounding tissue by GEPCI and immunohistochemical staining. Furthermore, these lesions were quantitatively differentiated from healthy tissue using GEPCI-derived metrics.

【 授权许可】

CC BY-NC