Rhodiola crenulata inhibits the tumorigenic properties of invasive mammary epithelial cells with stem cell characteristics

Dynamic Chiropractic

Sallie Smith Schneider¹  Adaris Rodriguez-Cortes²  Kelly J. Gauger³  Malgorzata Hartwich⁴ 

[1] Am Vollmersbusch 23, D-58706 Menden, Germany.;Biology Department, University of Massachusetts, Amherst, MA 01003, USA.;Pioneer Valley Life Sciences Institute, Baystate Medical Center, Springfield, MA 01199, USA.;Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01003, USA.

关键词: Breast cancer;    rhodiola;    metastasis;    stem cells;    CD44high/CD24low;    anoikis;    SFRP1;    Id-1;    Id-2;    Id-3.;   

DOI  :  10.5897/JMPR09.395

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

Rhodiolais a high altitude perennial plant that is widespread in Eastern Europe and Asia. The root of theRhodiolaplanthas been used for many years in eastern traditional medicine and it is well known for cardio-protective and central nervous system enhancement effects. It is considered a plant-derived “adaptogen” which is capable of maintaining a physiological homeostasis upon exposure to stress. TheRhodiola roseaandRhodiola crenulataspecies have been shown to elicit anti-tumor activitiesin vitroandin vivo. Here we show thatR. crenulatais able to block several characteristics associated with cancer stem cell behavior including migration, invasion, resistance to anoikis and tumorsphere formation. In addition, we show thatR. crenulataregulates the mRNA expression levels of Id (Inhibitor of differentiation or Inhibitor of DNA-binding) proteins, which play several key roles in development, cell cycle regulation and tumorigenesis.

【 授权许可】

Unknown