How do tenascins influence the birth and life of a malignant cell?

Journal of Cellular and Molecular Medicine

Florence Brellier¹ 

[1] Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Basel, Switzerland

关键词: tenascin;    genomic instability;    stem cells;    primary tumour;    EMT;    angiogenesis;    extracellular matrix;    metastasis;    mechanical forces;    cancer therapy;    microenvironment;    stroma;   

DOI  :  10.1111/j.1582-4934.2011.01360.x

来源: Wiley

【 摘 要 】

Abstract

• • Introduction
• • Birth of a malignant cell
• • Niches for self-renewable cells
• • Expression patterns in tumours
• • Promotion of tumour cell proliferation
• • Promotion of tumour cell migration
• • Contribution to epithelial–mesenchymal transition (EMT)
• • Promotion of angiogenesis
• • Promotion of metastasis
• • How do tenascins signal to cells?
• • Importance of the mechanical aspect
• • Evasion of tumour cells from conventional therapy
• • Conclusions

Tenascins are large glycoproteins found in embryonic and adult extracellular matrices. Of the four family members, two have been shown to be overexpressed in the microenvironment of solid tumours: tenascin-C and tenascin-W. The regular presence of these proteins in tumours suggests a role in tumourigenesis, which has been investigated intensively for tenascin-C and recently for tenascin-W as well. In this review, we follow a malignant cell starting from its birth through its potential metastatic journey and describe how tenascin-C and tenascin-W contribute to these successive steps of tumourigenesis. We consider the importance of the mechanical aspect in tenascin signalling. Furthermore, we discuss studies describing tenascin-C as an important component of stem cell niches and present examples reporting its role in cancer therapy resistance.

【 授权许可】

Unknown   
© 2011 The Authors Journal of Cellular and Molecular Medicine © 2011 Foundation for Cellular and Molecular Medicine/Blackwell Publishing Ltd