Dynamic Chiropractic | |
Caffeic acid and its derivatives as heme oxygenase 1 inducer in Hep G2 cell line | |
关键词: Caffeic acid; caffeic acid derivatives; heme oxygenase 1.; | |
DOI : 10.5897/JMPR10.129 | |
学科分类:医学(综合) | |
来源: MPA Media | |
【 摘 要 】
Effect of 10, 50 and 100 µg/ml caffeic acid and its esters and amides derivatives on heme oxygenase 1 (HO-1) activity induction in Hep G2 cell line was studied. It was found that caffeic acid ester derivatives could induce HO-1 activity more than amide derivatives. The longer side chain and aromatic side chain affected HO-1 activity. At 10 µg/ml concentration, phenylmethyl 1-(3’, 4’-dihydroxyphenyl) propenate (PMDP) had2.1-fold more activity when compared with control. At 50 and 100 µg/ml concentrations,phenylethyl 1-(3’, 4’-dihydroxyphenyl) propenate (PEDP) was the highest HO-1 inducer, whose activity was 2.1- and 2.3-fold greater, respectively, whencompared with the control group. Caffeic acid and all derivatives inducedHO-1activity on a higher level than curcumin, positive control. This study implied that caffeic acid and its derivatives could be used to induce HO-1 to protect tissues against free radicals.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201902024726463ZK.pdf | 155KB | download |