Caffeic acid and its derivatives as heme oxygenase 1 inducer in Hep G2 cell line

Dynamic Chiropractic

关键词: Caffeic acid;    caffeic acid derivatives;    heme oxygenase 1.;   

DOI  :  10.5897/JMPR10.129

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

Effect of 10, 50 and 100 µg/ml caffeic acid and its esters and amides derivatives on heme oxygenase 1 (HO-1) activity induction in Hep G2 cell line was studied. It was found that caffeic acid ester derivatives could induce HO-1 activity more than amide derivatives. The longer side chain and aromatic side chain affected HO-1 activity. At 10 µg/ml concentration, phenylmethyl 1-(3’, 4’-dihydroxyphenyl) propenate (PMDP) had2.1-fold more activity when compared with control. At 50 and 100 µg/ml concentrations,phenylethyl 1-(3’, 4’-dihydroxyphenyl) propenate (PEDP) was the highest HO-1 inducer, whose activity was 2.1- and 2.3-fold greater, respectively, whencompared with the control group. Caffeic acid and all derivatives inducedHO-1activity on a higher level than curcumin, positive control. This study implied that caffeic acid and its derivatives could be used to induce HO-1 to protect tissues against free radicals.

【 授权许可】

Unknown