Evaluation of the activity of Guatemalan medicinal plants against cancer cell lines and microbes

Dynamic Chiropractic

关键词: Anticancer;    antimicrobial;    IC50;    CC50;    minimum inhibitory concentrations (MIC);    Guatemala.;   

DOI  :  10.5897/JMPR2013.4478

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

Medicinal plants are used by rural Guatemalan villagers to treat a variety of ailments, and a better understanding of their effectiveness against common diseases is warranted. Acetone and methanol extractsof 73 medicinal plantspecies from 44 families were bio-assayed against breast,cervical, skin, and tongue cancers, andStaphylococcus aureus,Escherichia coli,Streptococcus mutans,Lactobacillus acidophilus, andCandida albicans. Half-maximum inhibitory concentrations (IC50) and half-maximum cytotoxicity concentrations (CC50) were determined against cancerous and non-cancerous cell lines, respectively. Minimum inhibitory concentrations (MIC) were determined for active extracts.Bursera simaruba(L.) Sarg. (Burseraceae),Byrsonima crassifolia(L.) Kunth (Malpighiaceae),GuazumaulmifoliaLam. (Malvaceae), andQuercus acatenangensisTrel. (Fagaceae) were inhibitory to one or more cancer cell lines and yielded promising IC50and CC50values.Eucalyptus globulusLabill. (Myrtaceae),Liquidambar styracifluaL. (Altingiaceae),Pelargonium hortorumL.H. Bailey (Geraniaceae), andPsidium guajavaL. (Myrtaceae) were inhibitory to one or more microbes and had MIC’s of 250 µg/ml or less against one or moremicrobes. The activity of these species against cancer and pathogenic microbes indicates that they are valuable resources that should be conserved and considered for future research.

【 授权许可】

Unknown