Antimicrobial activity, cytotoxicity and phytochemical screening of Ficus septica Burm and Sterculia foetida L. leaf extracts

Dynamic Chiropractic

Pierangeli G. Vital¹  Rogelio N. Velasco Jr.² 

[1] Institute of Biology, College of Science, University of the Philippines, Diliman, Quezon City 1101, Philippines.;Molecular Protozoology Laboratory, Natural Sciences Research Institute, University of the Philippines, Diliman, Quezon City 1101, Philippines.

关键词: Leaf extract;    antibacterial;    antifungal;    antiprotozoal;    cytotoxic;    phytochemical screening;    Ficus septica;    Sterculia foetida.;   

DOI  :  10.5897/JMPR09.400

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

Ethanol extracts of leaves ofFicus septicaBurm andSterculia foetidaL. were examined for their antibacterial, antifungal, antiprotozoal, and cytotoxic properties. To determine these activities, the extracts were tested against bacteria and fungus through disc diffusion assay; against protozoa through growth curve determination, antiprotozoal and cytotoxicity assays. The extracts revealed antibacterial activities, inhibiting the growth ofStaphylococcus aureusandEscherichia coli. Antifungal assay forF. septicaextract showed that it inhibitedCandida albicans. The antiprotozoal assay againstTrichomonas vaginalisshowed thatF. septicacan reduce the number of parasites. Moreover, antiprotozoal assays againstEntamoeba histolyticarevealed thatF. septicaandS.foetidacan inhibit the growth of the parasites, wherein the action can be comparable to metronidazole. With thein situcell death detection kit,T. vaginalisexposed toF. septicaandE. histolyticaexposed toF. septicaandS.foetidawere observed to fluoresce in red surrounded by a yellow signal signifying apoptotic-like changes. Preliminary phytochemical screening revealed the chemical composition ofF. septicaextracts containing alkaloids, quaternary base, tannins, 2-deoxysugars, and benzopyrone nucleus, whileS.foetidapossessing tannins, 2-deoxysugars, leucoanthocyanin, and benzopyrone nucleus. Thus, these plant extracts can possibly be used to produce alternative forms of antimicrobials.

【 授权许可】

Unknown