Effects of Amaranthus caudatus l. extract and lovastatin on atherosclerosis in hypercholesterolemic rabbits

Dynamic Chiropractic

Seddigheh Asgary¹  Najmeh Kabiri²  Parvin Mahzouni³  Hossein Madani⁴ 

[1]Department of Basic Sciences, 

[2]Department of Biology, Isfahan University, Isfahan, Iran.

[3]Department of Pathology, Faculty of Medicine, Isfahan University of Medical Sciences, Iran.

[4]Isfahan Cardiovascular Research Center, Applied Physiology Research Center, Isfahan University of Medical Sciences, WHO Collaborating Center, Isfahan, P. O. Box 81465-1148, Iran.

关键词: Atherosclerosis;    lipid;    Ox-LDL;    CRP;    Apolipoprotein;    Amaranthus caudatus;    Amaranthaceae.;   

DOI  :  10.5897/JMPR09.198

学科分类：医学（综合）

来源: MPA Media

【 摘 要 】

Coronaryartery disease (CAD), which is a multi-factorial disease frequently, causes morbidity and mortality in human beings. Scientists now believe that there is a good link between the inflammatory process and coronary atherosclerosis. A study was conducted to find out the anti- atherosclerosis effect of Amaranthus caudatus L. on rabbits, and was compared with lovastatin. Twenty five male New Zealand rabbits were randomly grouped into five and each were fed for 60 days with a standard diet, standard diet and cholesterol, standard diet andA. caudatus extract (150 mg/kg daily), standard diet and A. caudatus extract (150 mg/kg daily) with cholesterol, and standard diet with lovastatin (10 mg/kg) and cholesterol. At the 30thand 60thday of experiment, the biochemical factors were measured and the fatty streak formation was evaluated at the 60thday. Rabbits fed with high cholesterol diet and A. caudatus extract significantly decreased the cholesterol, LDL-C, triglyceride, oxidized LDL (Ox-LDL), apo-lipoprotein B (apoB), CRP, atherogenic index (AI) and HDL-C and apo-lipoprotein A (apoA) increased. Lesion severity, in extract recipient group, significantly decreased.A. caudatusextract decreased the most important risk factors (the serum lipoproteins, apoB and Ox-LDL) of cardiovascular diseases and inflammatory factors prevented atherosclerosis and was more effective than lovastatin.

【 授权许可】

Unknown