DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE ESTIMATION OF TRIFLUSAL IN BULK AND IN CAPSULE FORMULATION

Journal of The Chilean Chemical Society

SURANA, SANJAY J¹  REDASANI, VIVEKKUMAR K¹  VISPUTE, KULDIP R²  PATIL, VIJAYK² 

[1] R. C. Patel Institute of Pharmaceutical Education and Research, Dhule, India;R. C. Patel Institute of Pharmaceutical Education and Research, Maharashtra, India

关键词: Triflusal;    RP-;    HPLC;    Validation;    Specificity;    System suitability. ;    INTRODUCTION;   

DOI  :  10.4067/S0717-97072012000200026

学科分类：化学（综合）

来源: Sociedad Chilena de Quimica

【 摘 要 】

A simple, rapid, selective and sensitive RP-HPLC method was developed and validated for the estimation of triflusal. The method was carried out using 5-µm particle size, C18-bonded silica column, quaternary pump and acetonitrile: 1 mM potassium dihydrogen phosphate (65:35 v/v) pH 3 as the mobile phase with UV detection at 226 nm. The proposed method is advantageous as it follows isocratic elution in short run time (10 min). The result obtained shown that the method best fits for estimation of drug in capsule formulation and thus can be used for its routine analysis. The newly developed method was validated according to the ICH guidelines with respect to specificity, linearity, accuracy, precision and robustness.

【 授权许可】

Unknown