Reliance of Host Cholesterol Metabolic Pathways for the Life Cycle of Hepatitis C Virus

PLoS Pathogens

Jin Ye¹ 

关键词: Cholesterol;    Viral replication;    Lipoproteins;    Hepatitis C virus;    Lipids;    Lipoprotein receptors;    Drug therapy;    Structural proteins;   

DOI  :  10.1371/journal.ppat.0030108

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

Hepatitis C virus (HCV), a single-stranded positive-sense RNA virus of the Flaviviridae family, infects more than 170 million people worldwide and is the leading cause of liver failure in the United States. A unique feature of HCV is that the viral life cycle depends on cholesterol metabolism in host cells. This review summarizes the cholesterol metabolic pathways that are required for the replication, secretion, and entry of HCV. The potential application of drugs that alter host cholesterol metabolism in treating HCV infection is also discussed.

【 授权许可】

CC BY