Importance of the association of molecular and immunological diagnosis in immunocompetent patient with Histoplasma capsulatum and Cryptoccocus neoformans infection: a case report

Journal of venomous animals and toxins

Adriana Pardini Vicentini¹  Marcos Viní¹  Ká²  Valdelene Sayuri Kohara⁵  Roberta Scholz Pinto Garcia⁵  Roseli Santos de Freitas⁷  Edna Cleide Mendes Muricy⁸  cius da Silva⁹  tia Cristina Dantas⁹ 

[1] LIM 53/HCFMUSP and Institute of Tropical Medicine, University of SãDepartment of Pathology, Medical School, University of SãEmíImmunology Center, Adolfo Lutz Institute, SãLaboratory of Medical Mycology –lio Ribas Infectious Diseases Institute, São Paulo;o Paulo, Brazil;o Paulo, Sã

关键词: Immunocompetent individuals;    Nested PCR;    Immunoblotting;    Fungal infections;    Blood fluid;   

DOI  :  10.1186/1678-9199-20-36

学科分类：药理学

来源: BioMed Central

【 摘 要 】

This case reports an immunocompetent 29-year-old woman with suspected pneumonia, suggestive of fungal infection. Immunoblotting analysis reactivity against Histoplasma capsulatum and Paracoccidioides brasiliensis were observed. Nested-PCR in blood employing species-specific primers was positive for H. capsulatum and Cryptococcus neoformans. The evaluation of paucisymptomatic patients with positive results for H. capsulatum and C. neoformans could be relevant for the prevention as well as the possible evaluation of the reactivated quiescent foci. In conclusion, the associated methodology may have contributed to the monitoring endogenous reactivation of these diseases.

【 授权许可】

CC BY