CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breast

Biological research: BR

as¹  Irá¹  guez-Sanchez²  mez-Mací³  Oralia Barboza-Quintana³  Juan Pablo Flores-Gutierrez⁴  Laura Garcí⁴  Jesú⁵  guez⁶  s Ancer-Rodrí⁷  m Pablo Rodrí⁸  a Gó⁹  Raquel Garza-Guajardo⁹  a-Labastida^1,10  Gabriela Sofí^1,10 

[1] Eleuterio Gonzá, Departamento de AnatomíDr. JoséUniversidad Autóa Patolóa, Monterrey, Mexico;gica y Citopatologílez”n, Hospital Universitario “noma de Nuevo Leó

关键词: Breast mucinous carcinoma;    Inmunohistochemical;    Intestinal differentiation;   

DOI  :  10.1186/0717-6287-47-43

学科分类：生物科学（综合）

来源: BioMed Central

【 摘 要 】

Pure mucinous adenocarcinoma of the breast is a rare entity characterized by the production of variable amounts of mucin comprising 1% to 6% of breast carcinomas. Some mucinous adenocarcinomas have shown expression of intestinal differentiation markers such as MUC-2. This study examines the expression of intestinal differentiation markers in this type of breast carcinoma. Twenty-two cases of pure mucinous adenocarcinoma of the breast were assessed. Immunochemistry was performed for beta-catenin, CDX-2 and MUC-2. All cases were positive for B-catenin. MUC-2 positivity was observed in all cases; 63. 6% were 3 plus positive. All cases were negative for CDX-2. These results suggest that mucinous breast carcinomas express some markers of intestinal differentiation, such as MUC-2 and beta-catenin; however, future studies with a larger series of cases and using molecular techniques that help affirm these results are needed.

【 授权许可】

CC BY