Primary adenocarcinoma of the thymus: an immunohistochemical and molecular study with review of the literature

BMC Clinical Pathology

Yahya Daneshbod²  Abolfazl Saeedzadeh²  Reiner Siebert¹  Pablo Bejarano³  Inga Nagel¹  Mani Ramzi⁴  Maryam Maghbool² 

[1] Institute of Human Genetics, Christian-Albrechts University Kiel and University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany;Department of Molecular Pathology, Dr Daneshbod Pathology Laboratory, Shiraz, Iran;Department of Pathology, JMH/University of Miami School of Medicine, Miami, USA;Department of Hematology- Oncology, Shiraz University of Medical Sciences, Shiraz, Iran

关键词: Literature review;    Immunohistochemical study;    CGH array;    Molecular study;    Thymoma;    Thymic carcinoma;    Intestinal differentiation;    Primary adenocarcinoma;    Thymus gland;   

Others  :  1084944
DOI  :  10.1186/1472-6890-13-17

 received in 2013-01-02, accepted in 2013-05-22,  发布年份 2013

【 摘 要 】

Background

Primary adenocarcinoma of thymus is extremely rare.

Case presentation

This is a case of primary adenocarcinoma with intestinal differentiation and focal mucin production in the thymus. Thymic cyst was associated with this tumor. Intestinal differentiation was confirmed by immunohistochemical stain with positivity for CDX-2, CK20, villin, MOC31 and focal positivity of CK7. Array comperative genomic hybridization (CGH) analysis showed a complex pattern of chromosomal imbalances including homozygous deletion at the HLA locus in chromosomal region 6p21.32.

Conclusion

This rare tumor shows a similar genetic aberration with other studied thymic epithelial tumors.

【 授权许可】

   
2013 Maghbool et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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