Endometrioid adenocarcinoma with simultaneous endocervical and intestinal-type mucinous differentiation: report of a rare phenomenon and the immunohistochemical profile

Diagnostic Pathology

M Ruhul Quddus¹  W Dwayne Lawrence¹  C James Sung¹  Rebecca Buell-Gutbrod¹ 

[1] Department of Pathology and Laboratory Medicine, Women & Infants Hospital and the Warren Alpert Medical School of Brown University, 101 Dudley Street, Providence, RI 02905, USA

关键词: Goblet cells;    Intestinal differentiation;    Endometrioid adenocarcinoma;    Endometrium;   

Others  :  805849
DOI  :  10.1186/1746-1596-8-128

 received in 2013-02-28, accepted in 2013-06-21,  发布年份 2013

【 摘 要 】

Intestinal differentiation in the endometrium is rare with only case reports in the international literature. We describe a case of simultaneous endocervical and intestinal-type mucinous differentiation with goblet cells arising in a FIGO grade 1 endometrioid adenocarcinoma. The patient had no involvement of the myometrium, cervix, or extra-uterine sites. There were no intestinal metaplastic changes of the endocervical canal. The etiology of this change is unknown, although recent reports suggest an association with hyperestrogenism.

【 授权许可】

   
2013 Buell-Gutbrod et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

【 参考文献 】

• [1]Nieuwenhuizen L, Khalil MK, Naik VR, Othman NH: Prevalence of goblet cell metaplasia in endocervical and endometrial adenocarcinoma: a histochemical study. Malays J Med Sci 2007, 14:56-61.
• [2]Nicolae A, Goyenaga P, McCluggage WG, Preda O, Nogales FF: Endometrial intestinal metaplasia: a report of two cases, including one associated with cervical intestinal and pyloric metaplasia. Int J Gynecol Pathol 2011, 30:492-496.
• [3]Yasuda M, Katoh T, Hori S, et al.: Endometrial intraepithelial carcinoma in association with polyp: review of eight cases. Diagn Pathol 2013, 8:25. BioMed Central Full Text
• [4]Ribeiro-Silva A: Immunohistohemical features of a papillary squamous cell carcinoma of the endomertrium with transitional cell differentiation. Diagn Pathol 2007, 2:26. BioMed Central Full Text
• [5]Uehara K, Yasuda M, Ichimura T, et al.: Peritoneal granuloma associated with endometrial adenocarcinoma of the uterine corpus. Diagn Pathol 2011, 6:106. BioMed Central Full Text
• [6]Boyd C, Cameron I, McCluggage WG: Endometrial adenocarcinoma with signet ring cells: report of two cases of an extremely rare phenomenon. Int J Gynecol Pathol 2010, 29:579-582.
• [7]Abiko K, Baba T, Ogawa M, Mikami Y, Koyama T, Mandai M, Konishi I: Minimal deviation mucinous adenocarcinoma (‘adenoma malignum’) of the uterine corpus. Pathol Int 2010, 60:42-47.
• [8]McCluggage WG, Roberts N, Bharucha H: Enteric differentiation in endometrial adenocarcinomas: a mucin histochemical study. Int J Gynecol Pathol 1995, 14:250-254.
• [9]Moore WF, Bentley RC, Kim KR, Olatidoye B, Gray SR, Robboy SJ: Goblet-cell mucinous epithelium lining the endometrium and endocervix: evidence of metastasis from an appendiceal primary tumor through the use of cytokeratin-7 and −20 immunostains. Int J Gynecol Pathol 1998, 17:363-367.
• [10]Park KJ, Bramlage MP, Ellenson LH, Pirog EC: Immunoprofile of adenocarcinomas of the endometrium, endocervix, and ovary with mucinous differentiation. Appl Immunohistochem Mol Morphol 2009, 17:8-11.
• [11]Clement PB, Young RH: Endometrioid carcinoma of the uterine corpus: a review of its pathology with emphasis on recent advances and problematic aspects. Adv Anat Pathol 2002, 9:145-184.
• [12]Dallenbach-Hellweg G, Hahn U: Mucinous and clear cell adenocarcinomas of the endometrium in patients receiving antiestrogens (tamoxifen) and gestagens. Am J Pathol 1995, 14:7-15.