Conus vexillum venom induces oxidative stress in Ehrlich's ascites carcinoma cells: an insight into the mechanism of induction

Journal of venomous animals and toxins

Mohamed S El-Naggar¹  Ismail M Abdel-Nabi²  Mohamed A Abdel-Rahman²  Osama A Abbas²  Peter N Strong³ 

[1] Department of Biological Sciences, Faculty of Science, Taibah University, Madinah, KSA;Department of Zoology, Faculty of Science, Suez Canal University, Ismailia, Egypt;Department of Zoology, Faculty of Sciences, Port Said University, Port Said, Egypt

关键词: Conus vexillum venom;    Ehrlich’s cells;    Oxidative stress;    Cancer;    Egypt;   

DOI  :  10.1186/1678-9199-19-10

学科分类：药理学

来源: BioMed Central

【 摘 要 】

It is estimated that venoms of marine cone snails (genus Conus) contain more than 100,000 different small peptides with a wide range of pharmacological and biological actions. Some of these peptides were developed into potential therapeutic agents and as molecular tools to understand biological functions of nervous and cardiovascular systems. In this study we examined the cytotoxic and anticancer properties of the marine vermivorous cone snail Conus vexillum (collected from Hurgada and Sharm El-Shaikh, Red Sea, Egypt) and suggest the possible mechanisms involved. The in vitro cytotoxic effects of Conus venom were assessed against Ehrlich’s ascites carcinoma (EAC) cells. Conus venom treatment resulted in concentration-dependent cytotoxicity as indicated by a lactate dehydrogenase leakage assay. Apoptotic effects were measured in vivo by measuring levels of reactive oxygen species and oxidative defense agents in albino mice injected with EAC cells. Conus venom (1.25 mg/kg) induced a significant increase (p 

【 授权许可】

CC BY