Antibacterial activity of the phloroglucinols and hexanic extract from Hypericum brasiliense Choysi

Quimica nova

Rito, Priscila da Nóbrega¹  Teixeira, Lenise Arneiro¹  Oliveira, Adriana Passos de¹  Rocha, Leandro¹  Kuster, Ricardo Machado²  França, Hildegardo Seibert² 

[1] Universidade Federal Fluminense, Niterói, Brasil;Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil

关键词: Hypericumbrasiliense;    antibacterial activity;    phloroglucinol.;   

DOI  :  10.1590/S0100-40422009000500004

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Three phloroglucinols were obtained from Hypericum brasiliense: japonicine A (1), isouliginosin B (2) and uliginosin B (3). Bioautography and disk diffusion methods were used to determine antibacterial activity of the hexanic extract. Strains of the Coagulase Negative Staphylococcus and American Methicillin Resistant Staphylococcus aureus clones showed a growth inhibition zone ranging from 10 to 12 mm and 7 to 15 mm, respectively. Minimal inhibitory concentration (MIC) values were used to measure antistaphylococcal activity for all phloroglucinols. Isouliginosin B and uliginosin B presented MIC values of 1.5 and 3.0 µg/mL, respectively, while japonicine A displayed MIC value of 50.0 µg/mL.

【 授权许可】

CC BY