Plasmodium falciparum Infection Induces Expression of a Mosquito Salivary Protein (Agaphelin) That Targets Neutrophil Function and Inhibits Thrombosis without Impairing Hemostasis

PLoS Pathogens

Alvaro Molina-Cruz¹  Carlo J. Oliveira²  José M. C. Ribeiro³  Tainá Gomes⁴  Nidhi Gera⁴  Michalis Kotsyfakis⁴  Carolina Barillas-Mury⁴  Dongying Ma⁵  Robson Q. Monteiro⁵  Michael Waisberg⁶  Ivo M. B. Francischetti⁶  Beatriz C. Sousa⁶  Susan K. Pierce⁷  Daniella M. Mizurini⁷  Jan Lukszo⁷  Ana C. Leal⁷  Stephen F. Porcella⁸  Karine Reiter⁸ 

[1] Department of Pathology, University of Virginia, Charlottesville, Virginia, United States of America;Genomics Unit, Research Technology Section, Rocky Mountain Labs, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America;Institute of Parasitology, Academy of Sciences of the Czech Republic, České Budjovice, Czech Republic;Instituto de Bioquimica Médica, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil;Instituto de Ciências Biológicas e Naturais, Universidade Federal do Triângulo Mineiro, Uberaba, Brazil;Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America;Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America;Research Technology Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America

关键词: Neutrophils;    Antiport proteins;    Platelet aggregation;    Inflammation;    Plasmodium;    Thrombosis;    Chemotaxis;    Platelets;   

DOI  :  10.1371/journal.ppat.1004338

学科分类：生物科学（综合）

来源: Public Library of Science

【 授权许可】

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