Association of CYP2E1 genetic polymorphism with risk of Oral pre cancer and cancer in North Indian population

International Journal of Biomedical Research

关键词: Oral pre cancer;    cancer;    CYP2E1;    PCR-RFLP;    Gene polymorphism;   

DOI  :  10.7439/ijbr.v7i1.2877

学科分类：基础医学

来源: Scholar Science Journals

【 摘 要 】

Purpose: To evaluate the association of CYP2E1 promoter (-1091) C/T polymorphisms with the susceptibility of Oral pre cancer and cancer patients in North Indian population.Methods: A total 250 patients with oral pre cancer and cancer, 250 controls were genotypes for the CYP2E1 (C1091T) gene polymorphism. Genotypes were identified by polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP). Genotype frequencies were evaluated by Chi-square test and Odds ratio (OR) relative risk.Results: The average CYP2E1(C1091T) genotype frequencies of CC, CT and TT were calculated 80.80%, 5.20%, 14.00% in cases and 54.80%, 13.20% and 32.00% in healthy controls; respectively.Conclusion: We conclude that the CYP2E1 (C1091T) polymorphism was significantly associated in Oral pre cancer and cancer patients.

【 授权许可】

CC BY