Activation of HIV Transcription by the Viral Tat Protein Requires a Demethylation Step Mediated by Lysine-specific Demethylase 1 (LSD1/KDM1)

PLoS Pathogens

Melanie Ott¹  Katrin Kaehlcke²  Martina Schnoelzer²  Yasuhiro Mizusawa²  Sara Pagans²  Naoki Sakane²  Jonathan Chan²  Warner C. Greene²  Masafumi Kamada³  Kara G. Lassen³  Hye-Sook Kwon³ 

[1] Department of Medicine, University of California, San Francisco, United States of America;Gladstone Institute of Virology and Immunology, University of California, San Francisco, California, United States of America;Pharmaceutical Frontier Research Laboratory, Yokohama, Japan

关键词: HIV;    Acetylation;    Immunoprecipitation;    Flow cytometry;    T cells;    Lysine;    Transactivation;    Methylation;   

DOI  :  10.1371/journal.ppat.1002184

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

The essential transactivator function of the HIV Tat protein is regulated by multiple posttranslational modifications. Although individual modifications are well characterized, their crosstalk and dynamics of occurrence during the HIV transcription cycle remain unclear.

【 授权许可】

CC BY