期刊论文详细信息
Quimica nova | |
Synthesis of glycosyl-amino acids of biological interest | |
Campo, Vanessa Leiria1  Carvalho, Ivone1  | |
[1] Universidade de São Paulo, Ribeirão Preto, Brasil | |
关键词: glycosylated amino acids; glycosyldonors; glycosylation reaction.; | |
DOI : 10.1590/S0100-40422008000500015 | |
学科分类:化学(综合) | |
来源: Sociedade Brasileira de Quimica | |
【 摘 要 】
This work describes the synthesis of the glycosylatedamino acids αGlcNAc-Thr, βGlcNAc-Thr and αLacNAc-Thrby the glycosylation reaction of the amino acid threonine with the correspondingglycosyl donors αGlcNAcCl and αLacN3Cl. The glycosylatedamino acids containing the sugar units α-D-GlcNAc and α-D-LacNAcO-linked to threonine amino acids are related to O-glycans foundin mucins of the parasite Trypanosoma cruzi, while the correspondingβ-D-GlcNAc isomer is involved in cellular signaling events.
【 授权许可】
CC BY
【 预 览 】
Files | Size | Format | View |
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RO201902012490478ZK.pdf | 179KB | download |