Synthesis of glycosyl-amino acids of biological interest

Química Nova

Campo, Vanessa Leiria¹  Universidade de São Paulo, Ribeirão Preto, Brasil¹  Carvalho, Ivone¹ 

关键词: glycosylated amino acids;    glycosyl donors;    glycosylation reaction.;   

DOI  :  10.1590/S0100-40422008000500015

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

This work describes the synthesis of the glycosylated amino acids αGlcNAc-Thr, βGlcNAc-Thr and αLacNAc-Thr by the glycosylation reaction of the amino acid threonine with the corresponding glycosyl donors αGlcNAcCl and αLacN3Cl. The glycosylated amino acids containing the sugar units α-D-GlcNAc and α-D-LacNAc O-linked to threonine amino acids are related to O-glycans found in mucins of the parasite Trypanosoma cruzi, while the corresponding β-D-GlcNAc isomer is involved in cellular signaling events.

【 授权许可】

Unknown