The Plasmodium falciparum-Specific Human Memory B Cell Compartment Expands Gradually with Repeated Malaria Infections

PLoS Pathogens

Chiung-Yu Huang¹  Greta E. Weiss²  Shanping Li²  Susan K. Pierce²  Marko Mircetic²  Amy Baughman²  Peter D. Crompton²  Safiatou Doumbo³  Boubacar Traore³  Seydou Dia³  Younoussou Kone³  Kassoum Kayentao³  Agnes Guindo³  Ogobara K. Doumbo³  Didier Doumtabe³  Abdramane Traore³  Aissata Ongoiba³  Kazutoyo Miura⁴  Louis H. Miller⁴  David L. Narum⁴ 

[1] Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America;Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America;Malaria Research and Training Center, Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Bamako, Mali;Malaria Vaccine Development Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

关键词: Malaria;    B cells;    Malarial parasites;    Antibodies;    Convalescence;    Enzyme-linked immunoassays;    Memory B cells;    Vaccines;   

DOI  :  10.1371/journal.ppat.1000912

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

Immunity to Plasmodium falciparum (Pf) malaria is only acquired after years of repeated infections and wanes rapidly without ongoing parasite exposure. Antibodies are central to malaria immunity, yet little is known about the B-cell biology that underlies the inefficient acquisition of Pf-specific humoral immunity. This year-long prospective study in Mali of 185 individuals aged 2 to 25 years shows that Pf-specific memory B-cells and antibodies are acquired gradually in a stepwise fashion over years of repeated Pf exposure. Both Pf-specific memory B cells and antibody titers increased after acute malaria and then, after six months of decreased Pf exposure, contracted to a point slightly higher than pre-infection levels. This inefficient, stepwise expansion of both the Pf-specific memory B-cell and long-lived antibody compartments depends on Pf exposure rather than age, based on the comparator response to tetanus vaccination that was efficient and stable. These observations lend new insights into the cellular basis of the delayed acquisition of malaria immunity.

【 授权许可】

CC BY