DNA Damage Triggers Genetic Exchange in Helicobacter pylori

PLoS Pathogens

Jutta Fero¹  Marion S. Dorer¹  Nina R. Salama¹ 

[1] Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

关键词: DNA damage;    Helicobacter pylori;    DNA transcription;    DNA;    Stomach;    Microarrays;    Gene ontologies;    DNA repair;   

DOI  :  10.1371/journal.ppat.1001026

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

Many organisms respond to DNA damage by inducing expression of DNA repair genes. We find that the human stomach pathogen Helicobacter pylori instead induces transcription and translation of natural competence genes, thus increasing transformation frequency. Transcription of a lysozyme-like protein that promotes DNA donation from intact cells is also induced. Exogenous DNA modulates the DNA damage response, as both recA and the ability to take up DNA are required for full induction of the response. This feedback loop is active during stomach colonization, indicating a role in the pathogenesis of the bacterium. As patients can be infected with multiple genetically distinct clones of H. pylori, DNA damage induced genetic exchange may facilitate spread of antibiotic resistance and selection of fitter variants through re-assortment of preexisting alleles in this important human pathogen.

【 授权许可】

CC BY