Spectrophotometric olanzapine determination in pharmaceutical formulations: method development and validation

Quimica nova

Moura, Jacira Izidório de¹  Moita, Graziella Ciaramella¹  Rêgo, Jardes Figuerêdo do¹ 

[1] Universidade Federal do Piauí, Teresina, Brasil

关键词: olanzapine;    UV spectrophotometry;    validation.;   

DOI  :  10.1590/S0100-40422010000200041

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

Spectrophotometricmethods of zero order, first and second derived order had been developed forolanzapine determination in tablets using ethanol and isopropanol as solvent.The two solvents revealed to be adequate. For the three methods the calibrationcurve coefficient of correlation had been greater than 0.9998 with limit ofdetection varying from 0.068 to 0.190 mg L-1, in ethanol, and 0.026to 0.205 mg L-1, in isopropanol. The inter-day precision was inferiorto 1.1 and 1.9 mg L-1 for ethanol and isopropanol, respectively.The average recoveries varied from 98 to 101%, in ethanol and 99 to 103% inisopropanol.

【 授权许可】

CC BY