Determinação de olanzapina em formulações farmacêuticas por espectrofotometria: desenvolvimento e validação

Química Nova

Jardes Figuerêdo Do Rêgo¹  Jacira Izidório De Moura¹  Graziella Ciaramella Moita¹ 

[1] ,Universidade Federal do Piauí Departamento de Química Teresina PI ,Brasil

关键词: olanzapine;    UV spectrophotometry;    validation;   

DOI  :  10.1590/S0100-40422010000200041

来源: SciELO

【 摘 要 】

Spectrophotometric methods of zero order, first and second derived order had been developed for olanzapine determination in tablets using ethanol and isopropanol as solvent. The two solvents revealed to be adequate. For the three methods the calibration curve coefficient of correlation had been greater than 0.9998 with limit of detection varying from 0.068 to 0.190 mg L-1, in ethanol, and 0.026 to 0.205 mg L-1, in isopropanol. The inter-day precision was inferior to 1.1 and 1.9 mg L-1 for ethanol and isopropanol, respectively. The average recoveries varied from 98 to 101%, in ethanol and 99 to 103% in isopropanol.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License