Phytochemical study and evaluation of the molluscicidal activity of Calophyllum brasiliense Camb (Clusiaceae)

Quimica nova

Brenzan, Mislaine Adriana¹  Nakamura, Celso Vataru¹  Piloto, Izabel Cristina¹  Cortez, Diógenes Aparício Garcia¹  Gasparotto Jr., Arquimedes¹  Dias Filho, Benedito Prado¹  Ferreira, Antonio Gilberto²  Rodrigues Filho, Edson² 

[1] Universidade Estadual de Maringá, Maringá;Universidade Federal de São Carlos, São Carlos

关键词: Calophyllum brasiliense;    molluscicidal activity;    coumarin.;   

DOI  :  10.1590/S0100-40422005000400003

学科分类：化学（综合）

来源: Sociedade Brasileira de Quimica

【 摘 要 】

The bioassay-guidedfractionation against Biomphalaria glabrata of hydroalcoholic extractsof Calophyllum brasiliense aerial parts led to the isolation of the coumarin,named (-) mammea A/BB. The compound had its structure determined by both spectroscopictechniques (NMR 1H, NMR 13C, gHSQC, gHMBC and MS) and someliterature comparison data. The probit analysis of (-) mammea A/BB showedLD50 = 0.67 ppm and LD90 = 1.47 ppm. In addition, thedichloromethane extract obtained from C. brasiliense leaves with significantmolluscicidal activity against Biomphalaria glabrata was analyzed byHPLC-UV.

【 授权许可】

CC BY