Estudo fitoquímico e avaliação da atividade moluscicida do Calophyllum brasiliense Camb (Clusiaceae)

Química Nova

Arquimedes Gasparotto Jr.²  Mislaine Adriana Brenzan²  Izabel Cristina Piloto²  Diógenes Aparício Garcia Cortez²  Celso Vataru Nakamura¹  Benedito Prado Dias Filho¹  Edson Rodrigues Filho¹  Antonio Gilberto Ferreira¹ 

[1] ,Universidade Estadual de Maringá Departamento de Farmácia e Farmacologia Maringá PR

关键词: Calophyllum brasiliense;    molluscicidal activity;    coumarin;   

DOI  :  10.1590/S0100-40422005000400003

来源: SciELO

【 摘 要 】

The bioassay-guided fractionation against Biomphalaria glabrata of hydroalcoholic extracts of Calophyllum brasiliense aerial parts led to the isolation of the coumarin, named (-) mammea A/BB. The compound had its structure determined by both spectroscopic techniques (NMR ¹H, NMR 13C, gHSQC, gHMBC and MS) and some literature comparison data. The probit analysis of (-) mammea A/BB showed LD50 = 0.67 ppm and LD90 = 1.47 ppm. In addition, the dichloromethane extract obtained from C. brasiliense leaves with significant molluscicidal activity against Biomphalaria glabrata was analyzed by HPLC-UV.

【 授权许可】

CC BY-NC   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License