Brucella Control of Dendritic Cell Maturation Is Dependent on the TIR-Containing Protein Btp1

PLoS Pathogens

Alexandre Muller¹  Philippe Pierre¹  Lena Alexopoulou¹  Hugues Lelouard¹  Diego J Comerci²  Gilles Jolly²  Nicolas Lapaque²  Jean-Pierre Gorvel²  Suzana P Salcedo²  María Ines Marchesini³  Rodolfo A Ugalde³  Stephanie Balor³  Olivier Demaria³  Emilie Fugier⁴ 

[1] CNRS, UMR6102, Marseille, France;Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université, Faculté de Sciences de Luminy, Marseille, France;INSERM, U631, Marseille, France;Instituto de Investigaciones Biotecnológicas, IIB-INTECH Universidad Nacional de San Martin, San Martin, Buenos Aires, Argentina

关键词: Brucella;    Salmonellosis;    Salmonella;    Cytokines;    Macrophages;    Intracellular pathogens;    Salmonella typhimurium;    Secretion;   

DOI  :  10.1371/journal.ppat.0040021

学科分类：生物科学（综合）

来源: Public Library of Science

【 摘 要 】

Brucella is an intracellular pathogen able to persist for long periods of time within the host and establish a chronic disease. We show that soon after Brucella inoculation in intestinal loops, dendritic cells from ileal Peyer's patches become infected and constitute a cell target for this pathogen. In vitro, we found that Brucella replicates within dendritic cells and hinders their functional activation. In addition, we identified a new Brucella protein Btp1, which down-modulates maturation of infected dendritic cells by interfering with the TLR2 signaling pathway. These results show that intracellular Brucella is able to control dendritic cell function, which may have important consequences in the development of chronic brucellosis.

【 授权许可】

CC BY