| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Angiogenesis and wound repair: when enough is enough | |
| 关键词: wound healing; capillary; VEGF; scar; fibrosis; inflammation; | |
| DOI : 10.1189/jlb.4MR0316-102R | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
Allanimalsheal,andtheabilitytohealisrequisiteforhumanhealth.Oneaspectofrepairthathasalwaysbeenconsideredtobeessentialforadequatehealingisthecreationofanewvasculatureviaangiogenesis.Asadultskinwoundsheal,aperiodofrapidandrobustcapillarygrowthcreatesavascularbedthathasmanyfoldmorecapillariesthandoesnormaltissue.Overtime,mostofthenewlyformedcapillariesregress,resultinginafinalvasculardensitysimilartothatofnormalskin.Certainly,newcapillariesarenecessarytobringnutrients,immunecells,andoxygentohealingwounds.Yet,thepresumedfunctionalimportanceofanoverabundanceofcapillarieshasrecentlybeenchallenged,creatingquestionsaboutwhetherexcesscapillarygrowthistrulynecessaryforhealing.Inparticular,studiesofwoundsthathealexceptionallyquicklyandwithlessscarformation,suchasthoseinfetalskinandoralmucosa,showthatthesetissueshealwithareducedangiogenicburstcomposedofmorematurevesselsthatprovidebetteroxygenation.Thelevelofangiogenesisinwoundsoftencorrelateswiththeinflammatoryresponse,largelybecauseinflammatorycellsproduceanabundanceofproangiogenicmediators.Boththeselectivereductionofinflammationandtheselectivereductionofangiogenesishavenowbeensuggestedaswaystoimprovescarring.Theseconceptslinkexcessiveinflammationandtheproductionofadensebutpoorlyperfusedcapillarybedtoinferiorhealingoutcomes...
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| RO201901239193173ZK.pdf | 795KB |  download |
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