Biochemical and biomechanical characterization of porcine small intestinal submucosa (SIS): a mini review

International Journal of Burns and Trauma

Lei Shi¹ 

关键词: Small intestinal submucosa;    SIS;    extracellular matrix;    burn;    chronic wounds;   

DOI  :  

学科分类：外科医学

来源: e-Century Publishing Corporation

【 摘 要 】

Porcine small intestinal submucosa (SIS [Oasis®]) is an acellular, biological extracellular matrix (ECM) that has been found to significantly improve the healing of difficult-to-heal or chronic wounds in humans. Like dermal ECM, SIS contains collagen, elastin, glycosaminoglycans, proteoglycans, and growth factors that play important roles in healing. Preclinical studies have shown that numerous cell types attach to SIS, proliferate and migrate into the matrix, and differentiate. In addition, SIS can reduce the activity of matrix metalloproteinases (MMPs)—endogenous proteolytic enzymes whose levels and activities are increased in chronic wounds. Compared to the original single-layer SIS, multi-layer SIS has stronger mechanical properties and is more slowly degraded in wounds. Together, these SIS products provide flexibility in the selection of biologically-active ECMs that may be useful for the repair of diverse wound types.

【 授权许可】

CC BY-NC