Advances Toward Tissue Engineering for the Treatment of Stress Urinary Incontinence

Reviews in Urology

Ryan Pruchnic¹  Michael B Chancellor¹  Ron Jankowski¹  Michael Hiles¹ 

[1] Department of Urology, University of Pittsburgh, Pittsburgh, PA

关键词: Pubovaginal sling;    Small intestinal submucosa;    Stress urinary incontinence;    Xenografts;   

DOI  :  

学科分类：基础医学

来源: MedReviews, LLC

【 摘 要 】

Suburethral pubovaginal sling placement is a common surgical procedure for the treatment of stress urinary incontinence. A wide variety of graft materials is available, each associated with inherent desirable and undesirable characteristics and complications. In this article, we discuss the rationale for and application of small intestinal submucosa (SIS) in lower urinary tract tissue engineering, with emphasis on the use of SIS as a suitable and biologically compatible sling material. In addition, we discuss exciting research regarding the engineering of true functional sphincter reconstruction using this biologic scaffold and pre-seeded muscle cells.

【 授权许可】

Unknown