The SIRT 3 Expression Profile is Associated with Pathological and Clinical Outcomes in Human Breast Cancer Patients

Cellular Physiology and Biochemistry

关键词: SIRT 3;    Breast cancer;    Clinical characteristics;    Prognosis;   

DOI  :  10.1159/000366401

学科分类：分子生物学，细胞生物学和基因

来源: S Karger AG

【 摘 要 】

Aims To investigate the association of Sirtuin 3 (SIRT 3) expression between the clinical characteristics and prognosis in breast cancer patients. Methods 308 female patients with histologically confirmed breast cancer were enrolled in this study. The SIRT 3 expressions in tumor samples were detected. All the patients were followed up overall survival time (OS) and disease-free survival (DFS) time. Results SIRT 3 expression was significantly correlated with clinical characteristics including lymph node metastasis, pathological grade and tumor size of breast cancer. SIRT 3 expression status also affected the DFS and OS of breast cancer. Patients with high expression of SIRT 3 had shorter DFS and OS than those with low expression. Univariate and multivariate Cox analyses confirmed that high SIRT 3 expression predicted a poor prognosis in breast cancer patient. In vitro study revealed that the SIRT 3 knockdown by small interfering RNA technique dramatically reduced the proliferation, migration and invasion of breast cancer cell lines. Conclusion Our results suggest that SIRT 3 may serve as a marker for clinical feature and prognosis for breast cancer.

【 授权许可】

CC BY-NC-ND