Myeloid‐derived suppressor cells regulate T cell and B cell responses during autoimmune disease

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: autoimmune arthritis;    collagen‐;    induced arthritis;    rheumatoid arthritis;    immunotherapy;    chemokine receptor;   

DOI  :  10.1189/jlb.4A0314-139R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

MDSCsareaheterogeneousgroupofmyeloidcellsthatsuppressTcellactivityincancerandautoimmunedisease.TheeffectofMDSCsonBcellfunctionisnotclear.UsingtheCIAmodelofautoimmunedisease,wefoundanincreaseinM‐MDSCsintheperipheryofWTmicewithCIAcomparedwithnai¨vemice.TheseMDSCswereabsentfromtheperipheryofCCR2−/−micethatdevelopedexacerbateddisease.M‐MDSCs,isolatedfromimmunizedmice,inhibitedautologousCD4+Tcellproliferation.TheM‐MDSC‐mediatedsuppressionofTcellproliferationwasNOandIFN‐γdependentbutIL‐17independent.Furthermore,wedemonstratedforthefirsttimethatM‐MDSCsfromCIAmicealsoinhibitedautologousBcellproliferationandantibodyproduction.ThesuppressionofBcellsbyM‐MDSCswasdependentontheproductionofNOandPGE2andrequiredcell–cellcontact.AdministrationofM‐MDSCsrescuedCCR2−/−micefromtheexacerbatedCIAphenotypeandameliorateddiseaseinWTmice.Furthermore,adoptivetransferofM‐MDSCsreducedautoantibodyproductionbyCCR2−/−andWTmice.Insummary,M‐MDSCsinhibitTcellandBcellfunctioninCIAandmayserveasatherapeuticapproachinthetreatmentofautoimmunearthritis...

【 授权许可】

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