Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
New dog and new tricks: evolving roles for IL‐33 in type 2 immunity | |
关键词: ST2; innate‐; immune cells; immune response; fibrosis; T helper cells; | |
DOI : 10.1189/jlb.3RI1214-595R | |
学科分类:生理学 | |
来源: Federation of American Societies for Experimental Biology | |
【 摘 要 】
IL‐33isamorerecentlyidentifiedmemberoftheIL‐1cytokinefamily,expressedinthenucleusofepithelialcellsandreleasedintotheextracellularspacefollowingtissuedamage.TheimpactofIL‐33asaregulatoroftheadaptiveimmuneresponsehasbeenstudiedextensively,withanunderstoodroleforIL‐33intheeffectorfunctionsofCD4+Th2cells.IL‐33,however,isnowbeingshowntoinitiatetheTh2‐polarizingfunctionofDCs,andstimulatethesecretionofthetype2‐associatedcytokines,IL‐4,IL‐5,andIL‐13,fromtissue‐residentinnate‐immunecells,especiallyILCsandMCs.IL‐33alsoinitiatesandperpetuateslocalinflammatoryresponsesthroughtherecruitmentandactivationoftype2‐andinflammatory‐associatedeffectors,suchaseosinophils,basophils,andneutrophils.Assuch,IL‐33drivesandamplifiestype2‐dependentimmunity,aswellastype2‐dependenttissuedestructionandinflammation.ItisalsobecomingapparentthatIL‐33supportsthereparativecapacityofmacrophageandILCs,butthesefunctionsmayalsocontributetochronicfibroticdiseases.Herein,wereviewnewdevelopmentsintheunderstandingofIL‐33asitfunctionsinTh2cellsandtype2immunity.ThisincludesadiscussionofourevolvingunderstandingofhowIL‐33directlyandindirectlypromotestype2immuneresponsesthroughactiononinnatecellsinimmunityandthepathogenesisofatopicandfibroticdiseases...
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